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分子机制与疾病
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学术成果

Rangarajan ES, Bois JL, Hansen SB, & Izard T; High-resolution snapshots of the talin auto-inhibitory states. Nature Communications (2024) 15, Article number: 9270.

Yuan, Zixuan, Pavel MA, Hansen, SB*; GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons. Communication Biology April 22, 2025.

Hansen SB*; Yuan Z. Getting in on the action: New tools to see SARS-CoV-2 infect a cell. Cell chemical Biology (2023) 20(3), 233-234

Hansen SB*; Mechanisms of general anesthesia. Annual Reviews of Biochemistry (2025) 94 June, online Apr 1, doi: 10.1146/annurev-biochem-030222-121430

Petersen EN, Pavel MA, Hansen SS, Gudheti M, Ferris HA, Murphy KR, Ja WW, Jorgensen EM, Hansen SB*. Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling. (2024) eLife Jan 24, doi: 10.7554/eLif

Hansen SB*, Wang H. The shared role of cholesterol in neuronal and peripheral inflammation. Pharmacology & Therapeutics (2023) Jun 28;108486

Hansen SB*; Cholesterol’s function and origin in the Alzheimer’s brain. Journal of Alzheimer's Disease, (2023) Jun 29. doi: 10.3233/JAD-230538.

Wing PAC, Schmidt NM, Peteres R, Erdmann M, Brown R, Wang H, Swadling L, Newman J, Thakur N, Shionoya K, Morgan SB, Hinks, TSC, Watashi K, Bailey D, Hansen SB, Davidson AD, Maini M, McKeating JA; An ACAT inhibitor suppresses SARS-CoV-2 replication and boo

Wang H, Yuan Z, Pavel MA, Jablonski SM, Jablonski J, Hobson R, Valente S, Reddy CB, Hansen SB*; The role of high cholesterol in SARS-CoV-2 infectivity. J. Biol. Chem. (2023) April 4 104763

Yuan Z and Hansen SB*; Cholesterol regulation of membrane proteins revealed by two-color super-resolution imaging. Membranes (2023) Feb 20;13(2):250. doi: 10.3390/membranes13020250

Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall Nettles, Chakravarthy B. Reddy, Susana T. Valente, Scott B. Hansen*; Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mam

Hao Wang, Joshua Kulas, Chao Wang, David A. Holtzman, Heather A Ferris, Scott B. Hansen*; Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. Proc. Natl. Acad. Sci. (2021) 118 (33) e2102191118 https://doi.org/10.1073/pnas.21

Zachary J. Hauseman, Edward P. Harvey, Catherine E. Newman, Thomas E. Wales TE, Joel C. Bucci, Julian Mintseris, Davin K. Schweppe, Liron David, Lixin Fan, Daniel T Cohen, Henry D. Herce, Rida Mourtada, Yael Ben-Nun, Noah B Block, Scott B. Hansen, Hao Wu,

Mahmud Arif Pavel, E. Nicholas Petersen, Richard A. Lerner, Scott B. Hansen*; Studies on the mechanism of membrane mediated anesthesia. Proc. Natl. Acad. Sci (2020) Jun 16;117(24):13757-13766. doi:10.1073/pnas.2004259117

E. Nicholas Petersen, Mahmud Arif Pavel, Hao Wang, Scott B. Hansen*; Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels. BBA Biomembranes (2020) 1862 (1) pg1-9

Carol V. Robinson, Tibor Rohacs, Scott B. Hansen*; Tools for Understanding Nanoscale Lipid Regulation of Ion Channels. Trends Biochem Sci. (2019) Sep;44(9):795-806.

Mahmud Arif Pavel, Hae-Won Chung, E. Nicholas Petersen, Scott B. Hansen*; Polymodal Mechanism for TWIK-Related K+ Channel Inhibition by Local Anesthetic. Anesthesia & Analgesia (2019) Oct; 129(4):973-982. doi: 10.1213/ANE.0000000000004216.

Hae-Won Chung, E. Nicholas Petersen, Cerrone Cabanos, Keith R. Murphy, Mahmud Arif Pavel, Andrew S. Hansen, William W. Ja, Scott B. Hansen*; A Molecular Target for an Alcohol Chain-length Cutoff. JMB (2018) Dec 5;431(2):196–209. doi: 10.1016/j.jmb.2018.11

Cerrone Cabanos, Miao Wang, Xianlin Han, Scott B. Hansen*; A soluble fluorescent binding assay reveals PIP2 antagonism of TREK-1 Channels. Cell Reports, (2017) Aug 8;20(6):1287-1294. doi: 10.1016/j.celrep.2017.07.034

E. Nicholas Petersen, Hae-Won Chung, Arman Nayebosadri, Scott B. Hansen*; Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D. Nature Comm. (2016) Dec 15:7:13873. doi:10.1038/ncomms13873.

Scott B. Hansen* “Lipid Agonism; the PIP2 Paradigm of ligand gated ion channels” Biochim Biophys Acta (2015) May 1851 (5): 620-628.

Wang, H., Kulas, J.A., Higginbotham, H., Kovacs, M.A., Ferris, H.A., and Hansen, SB* (2023). Title: Regulation of neuroinflammation by astrocyte-derived cholesterol BioRxiv.

Scott B. Hansen, Xiao Tao, Roderick MacKinnon “Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2” Nature 2011, 477:495-98

Hansen SB, Wang, HL, Taylor P, and Sine SM “An Ion-Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance. J Biol Chem. 2008 Dec 26:283(52):36066-70

Hansen SB and Taylor P “Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non--subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors” J. Mol. Biol. 2007 June 369, 895-901

26. Gao F, Mer G, Tonelli M, Hansen SB, Burghart TP, Taylor P, Sine SM. “Solution NMR of Acetylcholine Binding Protein Reveals ACh-mediated Conformational Change of the C-loop” Mol Pharmacol. 2006 Oct 70(4): 1230-5

Hibbs RE, Johnson DA, Shi J, Hansen SB, and Taylor P “Structural Dynamics of the -Neurotoxin-Acetylcholine Binding Protein Complex: Hydrodynamic and Fluorescence Anisotropy Decay Analyses” Biochemistry 2005, 44:16602-11

Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y “Structures of Aplysia AChBP complexes with agonists and antagonists reveal distinctive binding interfaces and conformations” Embo J 2005, 24:3635-46

Bourne Y, Talley TT, Hansen SB, Taylor P and Marchot P “Crystal structure of a Cbtx-AChBP complex reveals essential interaction between snake -neurotoxins and nicotinic receptors” Embo J 2005, 24: 1512-22

Gao F, Bren N, Burghardt TP, Hansen SB, Henchman RH, Taylor P, McCammon JA, Sine SM. “Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence” J Biol Chem. 2005 Mar 4;280(9):844

Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, and Sine SM “Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel” Nature 2004 Aug 19:430:896-900

Hansen SB, Talley TT, Radic Z, and Taylor P. “Structural and ligand recognition characteristics of an acetylcholine binding protein from Aplysia californica” J Biol Chem. 2004 Jun 4:279(23):24197-202

Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, and Sine SM. “Curariform antagonists bind in different orientations to acetylcholine-binding protein” J Biol Chem. 2003 Jun 20;278(25):23020-6.

Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, and Taylor P. “Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein” J Biol Chem. 2002 Nov 1;277(44):41299-302.

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